Lipids
June 21, 2016
Regulation of HMG-CoA reductase and cholesterol metabolism
A short introduction about HMG-CoA reductase HMG-CoA reductase or 3-hydroxy-3-methylglutaryl coenzyme-A reductase is an endoplasmic reticulum membrane-bound enzyme. It catalyzes the conversion of HMG-CoA to mevalonate. This step, the formation of the mevalonate, is the rate-limiting step of cholesterol biosynthesis as well as the synthesis of …