Month: January 2017

 Insulin receptor (IR) is a member of receptor tyrosine kinases having a critical role in the insulin-mediated regulation of central metabolism, growth, and development. It is a tetramer of (αβ)2 type tyrosine kinase. Each αβ heterodimer is composed of an extracellular ligand-binding α subunit and transmembrane-spanning …

 Though proteins can be stored with cosolvents such as salts and polyols to enhance their stability and activity for biological and biotechnological applications, however, the mechanisms for protein stability remain elusive. Generally, these cosolvents promote the shifting of protein conformations towards a more compact form and …