Proteins are the workhorses of life. From the hemoglobin transporting oxygen in your blood to the enzymes breaking down your last meal, their function is dictated by one thing: shape. For decades, determining the 3D structure of a protein from its amino acid sequence—the “protein folding …
Introduction to AI in Biochemistry Artificial intelligence (AI) is reshaping the landscape of biochemistry, enabling breakthroughs in understanding life’s molecular processes, accelerating drug discovery, and redefining research paradigms. Biochemistry traditionally relies on complex experimental methods to explore biomolecules. Still, the integration of AI technologies—such as machine …
Depression is one of the most prevalent psychiatric disorders worldwide, affecting over 280 million people according to the World Health Organization. It is characterized by persistent sadness, loss of interest in pleasurable activities, fatigue, disturbances in sleep and appetite, cognitive impairment, and, in severe cases, suicidal …
Amino acids are the building blocks of proteins, and each amino acid is distinguished by the chemical nature of its side chain (R-group). Among the twenty standard amino acids, a small subset is characterized by aromatic side chains. Amino acids with aromatic side chains contain a …
The term epigenetics refers to the study of heritable changes in gene function that occur without alterations in the DNA sequence itself. Unlike genetic mutations, which modify the nucleotide code, epigenetic mechanisms influence how genes are expressed—essentially turning them “on” or “off” in response to developmental …
The regulation of gene expression is a cornerstone of molecular biology, determining how cells function, differentiate, and respond to environmental cues. One of the most crucial epigenetic mechanisms governing gene activity is histone modification. Histones are the structural proteins around which DNA is wrapped to form …
Buffers play a critical role in chemistry, biology, and medicine because they maintain a stable pH in solutions despite the addition of small amounts of acids or bases. Among the wide variety of buffer systems available, sodium acetate buffer is one of the most widely used …
This is the simplest online Tris-HCl buffer calculator I have developed for my users, allowing them to easily determine the amount of Tris-HCl and Tris-base needed to prepare a Tris-HCl buffer of the desired pH and concentration. When using this calculator, simply enter the desired …
What is Alanine Transaminase? Alanine transaminase (ALT), also known as serum glutamate-pyruvate transaminase (SGPT), is a crucial enzyme in the human body, primarily associated with liver health. Its measurement in blood tests is an essential diagnostic tool that provides insights into liver function and overall metabolic …
Introduction of Salkowski reagent Salkowski reagent is a well-established chemical solution used primarily for the qualitative and semi-quantitative detection of indole compounds, especially indole-3-acetic acid (IAA), the most common naturally occurring plant hormone in the auxin group. Named after the German chemist Ernst Leopold Salkowski, the …
Infobiochem
Cancer
February 23, 2025
Introduction Cancer research has made significant strides over the past few decades, improving detection methods, targeted treatments, and better patient outcomes. As a complex group of diseases, cancer requires a multifaceted approach that incorporates genetics, immunology, and cutting-edge technology. This article explores the latest advancements in …
Infobiochem
Cancer
February 23, 2025
Introduction of Pancreatic Adenocarcinoma: Pancreatic adenocarcinoma is the most common type of pancreatic cancer, accounting for approximately 90% of cases. It is an aggressive malignancy with a high mortality rate, largely due to its asymptomatic early stages and late diagnosis. Despite advancements in medical research, the …
